systemic sclerosis review article

SSc is divided into diffuse cutaneous (dcSSc) and limited cutaneous (lcSSc) forms based on … Systemic sclerosis is a rare disease. Systemic sclerosis is diagnosed in approximately 67 male patients and 265 female patients per 100,000 people each year. Abstract Systemic sclerosis (SSc) is an orphan disease characterised by autoimmunity, fibrosis of the skin and internal organs, and vasculopathy. Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that is characterised by fibrosis of the skin and internal organs and vasculopathy. Systemic sclerosis (SSc) is a connective tissue disease that usually affects women, with a male:female ratio of 1:4–10. Systemic sclerosis (SSc) is a connective tissue disease that usually affects women, with a male:female ratio of 1:4–10.

SSc conveys a higher risk for CVD associated with both vascular and fibrotic complications during the course of the disease. Systemic sclerosis is an autoimmune disease characterized by vasculopathy-induced fibrosis of the skin and organs that can be life-threatening. Systemic sclerosis is diagnosed in approximately 67 male patients and 265 female patients per 100,000 people each year… Summary. In this article, we aim to review current knowledge about large-vessel involvement and CVD in SSc and discuss the potentially implicated pathogenetic mechanisms. This review is an updated report on … SSc may … SSc is an orphan autoimmune disorder with significant morbidity and mortality. Systemic sclerosis is a rare disease. TLRs are involved in the pathogenesis of Systemic Sclerosis and are activated by endogenous mediators (“danger signals”). Although there has been significant progress over the years in therapeutic options for SSc, the mainstays of treatment are organ based and primarily symptom management. Although systemic sclerosis is uncommon, it has a high morbidity and mortality. Review Article. SSc is an orphan autoimmune disorder with significant morbidity and mortality. Review Article.

TLRs are involved in the pathogenesis of Systemic Sclerosis and are activated by endogenous mediators (“danger signals”). Abstract Systemic sclerosis (SSc) is an orphan disease characterised by autoimmunity, fibrosis of the skin and internal organs, and vasculopathy. This review is an updated report on … Although systemic sclerosis is uncommon, it has a high morbidity and mortality. Systemic sclerosis (SSc) is a chronic, multisystem connective tissue disease characterized by microangiopathy leading to inflammation and fibrosis involving skin and internal organs. Although there has been significant progress over the years in therapeutic options for SSc, the mainstays of treatment are organ based and primarily symptom management. Systemic sclerosis is an autoimmune disease characterized by vasculopathy-induced fibrosis of the skin and organs that can be life-threatening. In this article, we aim to review current knowledge about large-vessel involvement and CVD in SSc and discuss the potentially implicated pathogenetic mechanisms. SSc conveys a higher risk for CVD associated with both vascular and fibrotic complications during the course of the disease. Summary. Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that is characterised by fibrosis of the skin and internal organs and vasculopathy. SSc may be associated with high morbidity and mortality.